Figure 5.

Direct quantitation of contrast agent binding utilizing ¹⁹F CMR and fibrin-targeted PFC nanoparticles. (a) Optical image ex vivo of a 5-mm cross section of a human carotid endarterectomy sample. This section showed moderate luminal narrowing as well as several atherosclerotic lesions. (b) A ¹⁹F projection image acquired at 4.7 T through the entire carotid artery sample shows high signal along the lumen due to nanoparticles bound to fibrin. (c) Concentration map of bound nanoparticles in the carotid sample. Reprinted with permission from Morawski, et al [74].