Table 5.
PNA Glu-Oct6-13410a Induced Apoptosis in DU-145 and PANC-1 Cells
| DU-145 | |||||
|---|---|---|---|---|---|
| nM PNA | 0 | 300 | 600 | 1000 | 13410a |
| % apop. | 0.05 | 8.7 | 48.7* | 82.5* | 2.9 |
| SD | 0.04 | 7.7 | 24.1 | 5.9 | 4.6 |
| PANC-1 | |||||
| nM PNA | 0 | 300 | 600 | 1000 | 13410a |
| % apop. | 0.3 | 17.4 | 69.6* | 84.6* | 1.1 |
| SD | 0.2 | 14.6 | 5.9 | 14.6 | 0.8 |
Cells were incubated with PNAs Glu-Oct6-13410a or 13410a for 48 hr, at which time they were harvested and stained with FITC-annexin V plus PI, then apoptosis was quantified by flow cytometry. PNA 13410a was added at 1000 nM. The percents apoptosis are the means of 3 experiments; SD = standard deviation.
* p < 0.01 by repeated ANOVA