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5-HT fails to induce hypothermia in 5-HT7−/− mice. Time course of hypothermia after an i.p. injection of 5-HT (5 mg/kg) or vehicle in 5-HT7+/+ or 5-HT7−/− mice. The symbols represent 5-HT7+/+ vehicle (○), 5-HT7−/− vehicle (●), 5-HT7+/+ 5-HT (□), and 5-HT7−/− 5-HT (■), respectively. **, P < 0.01 for 5-HT-treated vs. vehicle-treated of the same genotype. ★, P < 0.05; ★★, P < 0.01 for 5-HT7+/+ vs. 5-HT7−/− mice treated with 5-HT. Data represent mean ± SEM; n = 6–10 mice per group.
