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. 2010 Nov 18;6(11):e1001214. doi: 10.1371/journal.pgen.1001214

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Schulz et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A, Bisulfite genomic sequencing of ICRs associated with the H19 and Kcnq1ot1 loci. The paternally methylated H19 ICR was methylated in wildtype (MP) and in maternal imprint-free (0P) but unmethylated in imprint-free (00) visceral yolk sacs. The maternal Kcnq1ot1 ICR was hypomethylated in both 0P and 00 material, in agreement with the lack of maternal imprints in these embryos. Nucleotide positions are reported in reference to the gene transcription start (+1). B, Normal methylation of LINE1 and IAP retrotransposons in MP, 0P, and 00 8.5dpc embryos as established by DNA blot hybridization after cleavage with the methylation-insensitive restriction endonuclease MspI or the methylation sensitive isoschizomer HpaII.