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. 2010 Nov 18;6(11):e1001215. doi: 10.1371/journal.pgen.1001215

Figure 2. RACK-1 is required for VD/DD motor axon pathfinding.

Figure 2

All panels are micrographs of animals with unc-25promoter::gfp expression (juIs76 transgene) in the VD/DD GABAergic motor neurons. The scale bar in A represents 10 µm for all panels. (A and B) Wild type and rack-1(RNAi) showing the DD1/VD2 commissure on the left side of the animal. Misrouted and branched axons are indicated by an arrow. Dorsal is up, and anterior is left. (C and D) Dorsal views of the dorsal nerve cords (marked by a D) of wild type and rack-1(tm2262). This dorsal view allows for demonstration of the sidedness of axon pathfinding. The cell bodies in the ventral nerve cord are out of focus (marked by a V). The arrow in C points to the DD1/VD2 commissure on the left side of the animal. All other VD/DD commissures go up the right side. Arrows in D point to VD/DD commissures that aberrantly extend up the left side of the animal in rack-1(tm2262). (E and F) VD/DD commissures in wild type and rack-1(tm2262). The arrow in F points to a misguided axon.