Figure 2. The perturbed functional network is a protein-protein interaction (blue edges) network.

This network includes the uniform functional sub-network (triangular nodes) which shares one biological function and all drug targets (grey nodes) interacting with it. Bafetinib (Bafe) can impact nodes (red border) in the uniform functional sub-networks in two ways: Either the drug inhibits directly a node in the uniform functional sub-network (1) or it modulates the function through peripherally interacting drug targets (2).