Figure 4. The bafetinib targets (grey nodes) perturb EGFR signaling which suggests a new application in lung cancer.

The drug profile interferes with many nodes of the uniform function sub-network (triangular nodes). The drug affinity is indicated by the node size (a large node means high affinity). Kinases in the target profile have a red label. Proteins of the uniform functional sub-network interacting with inhibited kinases are shown with a red node border. EGFR expressing cells are not known to carry the fusion protein BCR-ABL which diminishes the influence of BCR-ABL on the network (dashed lines).