Table 1. Significantly perturbed functional sub-networks named by their basic function.

Perturbed functional sub-networks	Nodes	Targets (competed)	Score s net
Epidermal growth factor receptor signaling pathway	57	25 (7)	0.213
Insulin receptor signaling pathway	68	26 (7)	0.198
Aging	96	29 (7)	0.185
Regulation of MAP kinase activity	94	22 (7)	0.162
Induction of apoptosis by intracellular signals	53	19 (5)	0.135
Extracellular structure organization and biogenesis	81	21 (6)	0.135
MAPKKK cascade	188	29 (8)	0.131
Heart development	104	21 (7)	0.127
Protein amino acid autophosphorylation	71	21 (5)	0.126
Cell cycle arrest	73	21 (5)	0.125

(Randomization: N = 500; p-value<0.002).