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Intracytoplasmic cytokine production by day 14 anti-CD3 stimulated CD8 T cells stimulated for 4 hours with PMA/A23187. By comparison to CD27- cells, the CD27+ subset produced little intracytoplasmic (A) tumor necrosis factor (TNF-α) or (B) interferon- γ (IFN-γ). Similar results were obtained in each of 4 studies.
