Table 3.

Strain-dependent gene regulation

Gene Name	p-value	log2 fold change	Description
E/C 8 up
NCE103	2.39E-02	1.15	Carbonic anhydrase, involved in a non-classical protein export pathway
PFK3	1.06E-02	1.34	Pichia pastoris 6-phosphofructokinase gamma-subunit
ERG25	3.29E-03	1.48	Required in the ergosterol biosynthesis pathway
AQR1	3.99E-02	1.67	Multidrug transporter of the major facilitator superfamily
E/C 8 down
YCT1	3.20E-04	- 3.21	High-affinity cysteine-specific transporter
FLR1	4.08E-02	- 1.15	Plasma membrane multidrug transporter

List of differently regulated genes (p-value ≤ 0.05 and a log2 fold change ≥ 0.59) in both strains under hypoxic (8) conditions. E/C 8 up corresponds to the upregulated genes in the expressing strain (E) as compared to the control strain (C), while the downregulated genes are referred to as E/C 8 down.