Figure 2.

Suppressive effect of tumor cell-associated podoplanin on lymph node metastasis in our animal model. A) The time-dependent tumor volume derived from each established clone in a tumor implantation model was measured and evaluated as described in Methods. (N.S. versus V1). B) The incidence of lymph node metastasis of each group was evaluated as described in Methods (**p < 0.001 versus V1, *p < 0.05 versus V1, N.S. versus V1). C) Representative metastatic foci in axillary lymph nodes of mice with implanted tumors are indicated (arrows).