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mROC graph representations of sensitivities and specificities of the combination of EP (black curve) or LP (grey curve) biomarkers. The mROC linear equations for decision rule are ZEP = -1.547 × [S2*] +0.466 × [S3*] + 0.661 × [S4*] + 1.238 × [S1*]; ZLP = 0.295 × [M1*] + 0.397 × [M5*] + 0.176 × [M6] + 0.399 × [M7*] * with λS1= 0.05, λS2 = -0.17, λS3 = 0.32, λS4 = 0.44, λS5 = -0.18, λS7 = 0.01 where λ is the coefficient of Box-Cox transformation: (S* = (Sλ-1)/λ)
