Table 6.
Group 1 (trekkers) (n = 198) - Testing performed at each laboratory
| Sea Level | Kathmandu (1300 m) |
Namche (3500 m) |
Pheriche (4250 m) |
EBC (5300 m) |
|
|---|---|---|---|---|---|
| Subjects at laboratory | 198 | 198 | 197 | 195 | 190 |
| CORE STUDIES | |||||
| Daily diary | 198 | 195 | 196 | 194 | 190 |
| CPX Ramp (+NIRS) | 190* | 189 | 184 | 183 | 153 |
| CPX ME | 195** | n/a | 191 | n/a | 164 |
| Spirometry | 198 | 197 | 190 | 176 | 185 |
| Venesection | 198 | 198 | 195 | 194 | 181 |
| Neurocognitive | 198 | 160 (on return) | 195 | n/a | 185 |
| Pupillometry | 198 | n/a | 191 | n/a | 186 |
| Cranial measurements | 198 | n/a | n/a | n/a | n/a |
| Retinal photography | 183 | n/a | n/a | n/a | 183 |
| Plasma biomarkers | 198 | 198 | 195 | 194 | 181 |
| ADDITIONAL STUDIES | |||||
| Hypoxic Pulmonary Vasoconstriction | 31 screened 13 selected | n/a | 11 | n/a | 11 |
| Smell and taste | 59 | n/a | n/a | n/a | 59 |
| Sleep | n/a | n/a | n/a | n/a | 15 |
| Oxygen Delivery Circuit | n/a | n/a | n/a | n/a | 6 |
| Cardiac MRI and 31P-MRS | 7 | n/a | n/a | n/a | n/a |
| Skeletal Muscle MRI and 31P-MRS[23] | 7 | n/a | n/a | n/a | n/a |
| Structural and Volumetric MRI Study | 7 | n/a | n/a | n/a | n/a |
* 6 subjects withdrawn from incremental CPET prior to departure and 2 because of poor baseline data quality
** 3 subjects withdrawn from efficiency CPET prior to departure