Table 3.
Association of HIV-1 co-receptor usage with the net charge of V3 loop
| Characteristic | Distribution b and frequency c of net charge of V3 loop | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Groups | tropism | Na | Mean ± Std | 2(%) | 3(%) | 4(%) | 5(%) | 6(%) | 7(%) |
| Drug-naïve | R5 | 66 | 3.91 ± 1.05 | 3(3.7) | 22(27.2) | 25(37.9) | 12(18.2) | 2(3.0) | 2(3.0) |
| X4/R5 | 15 | 4.53 ± 0.74 | 0 | 9(60.0) | 4(26. 7) | 2(13.3) | 0 | ||
| ART | R5 | 20 | 3.75 ± 1.21 | 1(5.0) | 7(35.0) | 7(35.0) | 3(15.0) | 2(10.0) | 0 |
| X4/R5 | 22 | 4.86 ± 1.25 | 1(4.6) | 3(13.6) | 5(22.7) | 4(18.2) | 7(31.8) | 2(9.1) | |
Note: a: the number of cases;
b:it is the net charge of V3 loop according to the formula (V3 net charge=(R+K)-(D+E));
c:it is the frequency of b in the a.
bold: No. of net charge of V3 for R5-tropic viruses distributed mainly below 4, occupied more than 70%;
bold and italic: No. of net charge of V3 for X4-tropic viruses distributed mainly above 4 in drug-naïve group, above 5 in ART group, occupied more than 60%