Table 4.
Predictive values of the cirrhosis algorithm and of liver biopsy, FibroScan and FibroTest for the prediction of HCV-related severe events occurrence, ANRS CO 13 HEPAVIH cohort of HIV-HCV co-infected patients
| HCV-related severe eventsa | |||||
|---|---|---|---|---|---|
| Absence (n) | Presence (n) | PPV (%) | NPV (%) | ||
| Algorithm* N=987 | Absence of cirrhosis | 752 | 4 | 12.5 | 99.5 |
| Presence of cirrhosis | 203 | 29 | |||
| Liver Biopsy N=192 | Metavir < F4 | 161 | 2 | 10.3 | 98.8 |
| Metavir F4 | 26 | 3 | |||
| FibroScan N=806 | <12.5KPa | 653 | 4 | 7.4 | 99.4 |
| ≤ 12.5 KPa | 138 | 11 | |||
| FibroTest N=718 | Metavir < F4 | 528 | 7 | 8.2 | 98.7 |
| Metavir F4 | 168 | 15 | |||
* See definition in Methods section; PPV: positive predictive value; NPV negative predictive value
a HCV-related severe events: ascites, varices bleeding, hepatic encephalopathy, hepatocellular carcinoma or HCV-related death