. Author manuscript; available in PMC: 2012 Jan 27.

Published in final edited form as: Vet Microbiol. 2010 Jul 22;147(3-4):310–319. doi: 10.1016/j.vetmic.2010.07.016

Table 4.

Pathogenicity in specific-pathogen-free chickens experimentally inoculated with capped RNA transcripts from infectious cDNA clones of avian HEV-VA strain (pT7-aHEV-VA) recovered from a healthy chicken, and avian HEV-prototype strain (pT7-aHEV-5) recovered from a chicken with HS syndrome.

Group	Lesion score^a (Mean±SD)				Liver/Body weight ratio^b (Mean±SD)
	Liver		Spleen		Liver/Body weight ratio^b (Mean±SD)

	3 wpi	5 wpi	3 wpi	5 wpi	3 wpi	5 wpi
Avian HEV-VA (pT7-aHEV-VA)	2.2 ± 0.84a^c	2.4 ± 0.89a	1.8 ± 0.4a	1.6 ± 0.55a	25.18 ± 2.22a	26.20 ± 2.63b
Avian HEV-prototype(pT7-aHEV-5)	2.6 ± 1.52a	3.0 ± 0.82a	2.2 ± 0.84a	1.5 ± 0.58a	26.56 ± 1.53a	27.25 ± 1.42b
PBS (Negative control)	2.6 ± 0.89a	2.0 ± 1.58a	1.4 ± 0.55a	1.0±1.0a	24.21 ± 3.09a	21.04 ± 1.84a

Liver lesion scores range from 0 to 4 (0, no lesions; 1, <5 foci; 2, 5–8 foci; 3, 9–15 foci; 4, >15 foci; the numbers of foci were bond on a single shade). Spleens were scored from 0 to 3 (0, normal; 1, minimal; 2, moderate; 3, severe).

Liver to body weight ratio was calculated by (liver weight)/(body weight) ×1000 and presented as the mean ± SD from each group.

Values followed by different lowercase letters are significantly different (p < 0.05).