Fig. 45.

a Transmission electron micrograph of negatively stained virus-like particles obtained from functionalized gold nanoparticles (black centers, 12 nm diameter) and BMV capsid protein. b Comparison of encapsulation yields for citrate: Au with the previous protocol8, Au:TEG, and native RNA. Averaged transmission electron micrograph of c empty BMV capsid, d citrate-coated VLP, and e TEG-coated VLP. The averages have been obtained by the superposition of 10 individual images, in each case. Reprinted with permission from Chen et al. (2006). Copyright: 2006 American Chemical Society