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RTV-induced activation of ICl,swell was reversed by ebselen, a H2O2 scavenger. (A) Currents in control (Ctrl), after RTV exposure (15 μM, 20 min), and after addition of ebselen (15 μM, 15 min) in presence of RTV. (B) I-V relationships from A. (C) Current densities at +60 mV (n = 5; Ctrl vs. RTV, P <0.001; RTV vs. +Ebselen, P <0.001; Ctrl vs. +Ebselen, P = 0.81).
