TABLE 1.

Dissociation constants and kinetic parameters as determined by SPR analysis

Ligand	Analyte	KD	kon	koff
		μm	m−1s−1	s−1
G10-loop	NPM1-C70	7.2 ± 0.2	2.8 ± 0.1 × 102	1.98 ± 0.03 × 10−3
	NPM1-C53	169 ± 5
T10-loop	NPM1-C70	307 ± 7
	NPM1-C53	1170 ± 40
G5-loop	NPM1-C70	40 ± 3
	NPM1-C53	224 ± 6
Poly(T)	NPM1-C70	120 ± 26
	NPM1-C53	520 ± 30
Poly(G)	NPM1-C70	5.8 ± 0.8
	NPM1-C53	31 ± 4
c-Myc	NPM1-C70	1.9 ± 0.1	7.4 ± 0.3 × 103	1.37 ± 0.03 × 10−2
	NPM1-C53	82 ± 15