FIGURE 6.

High-fat diet fed AMPK β2 KO mice gain more weight over time and are more susceptible to glucose intolerance and hyperinsulinemia. A, body mass over time in WT and β2 KO mice. B, hyperinsulinemia in AMPK β2 KO mice fed a HFD. C and D, impaired glucose tolerance in β2KO mice fed a HFD. E, serum insulin levels in chow and HFD-fed mice 20 min after injection with glucose (1 mg/kg). F and G, whole body insulin sensitivity following a bolus of insulin (0.75 units/kg). Values are mean ± S.E., n = 7–13. *, p < 0.05 compared with wild type. #, p < 0.05 compared with chow diet.