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Lipid-associated Aβ accumulates in NPC1, Sandhoff and GM1 mouse brains. Endogenous murine Aβ40 was measured in the brains of NPC1, Sandhoff, and GM1 mice. A, histogram of total Aβ40 measured from the sum of DEA and RIPA extracts in each mouse model (n = 4, mean ± S.E.). B, histogram of DEA soluble Aβ40 measured in each mouse model (n = 4, mean ± S.E.). C, histogram of RIPA soluble Aβ40 measured from each mouse model (n = 4, mean ± S.E.).
