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. 2010 Sep 24;285(48):37650–37662. doi: 10.1074/jbc.M110.138818

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 9. — Phosphorylation of Ser-1356 and Ser-1364 is involved in the regulation of EGF-induced keratinocyte migration. PA-JEB/β4^WT, PA-JEB/β4^R1281W, PA-JEB/β4^{S1356A/S1364A}, and PA-JEB/β4^{S1356D/S1364D} were cultured until confluency and starved overnight in growth factor-free medium. A, scratch was introduced prior to EGF stimulation. Wound closure is illustrated at different time-points (0, 5, 10, and 15 h). B, data represent the mean ± S.E. of three independent experiments performed in triplicate. C, averaged velocities of single migrating PA-JEB/β4^WT, PA-JEB/β4^{S1356A/S1364A}, and PA-JEB/β4^{S1356D/S1364D} keratinocytes on Ln-332 before and after the addition of EGF. Note that PA-JEB/β4^WT behave like PA-JEB/β4^{S1356A/S1364A} keratinocytes in the absence, and like PA-JEB/β4^{S1356D/S1364D} keratinocytes in the presence of EGF. Data represent the mean ± S.E. of ∼200 keratinocytes per cell line pooled from two independent experiments.