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Features of the regulatory motif in the p53 DNA-binding domain. The multiprotein binding site in the p53 core DNA-binding domain (highlighted in yellow) has a conformationally flexible motif (24) (i), MDM2-docking site or ubiquitination signal (22, 40) (ii), kinase docking site (25, 26, 29) (iii), and novel phosphorylation site at Ser269 (this study) (iv).
