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The multiprotein docking sites within the p53 DNA-binding domain. Protein-protein contacts in the conformationally flexible ubiquitination signal from the DNA-binding domain of p53. The key residues involved in MDM2, Chk2, and CK1a binding (arrows) and the contact sites for the DO-12 monoclonal antibody (green) are highlighted. The bottom panel indicates the positioning of key residues in the region known to influence p53 stability.
