Fig. 8.

DNase I footprinting assays. (a) The radiolabeled MS1-198 bp (lanes “0”) or (c) TTAA-69 bp DNA fragments were incubated alone (lanes “DNA”) or in the presence of graded concentrations (μM) of the various compounds as indicated on the top of each lanes. Lanes “G” correspond to the G-track ladders that were used as markers for guanines positions to locate the protected sites. The respective densitometric analyses are presented in panels (b) and (d). Black boxes localize the sites that are protected by the compounds from DNase I cleavage.