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. Author manuscript; available in PMC: 2010 Nov 19.
Published in final edited form as: JAMA. 1995 Mar 15;273(11):876–879. doi: 10.1001/jama.273.11.876

Figure 1.

Figure 1

Two-way paradigm (organ). Bidirectional mechanism of whole organ graft acceptance involving a graft-vs-host (GVH) reaction by the bone marrow–derived donor leukocytes in the graft that are pitted against the whole recipient immunologic apparatus (host-vs-graft [HVG], rejection). For standard whole organ clinical transplantation, the recipient is not preconditioned.