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. Author manuscript; available in PMC: 2011 Nov 10.
Published in final edited form as: DNA Repair (Amst). 2010 Aug 25;9(11):1119–1129. doi: 10.1016/j.dnarep.2010.07.014

Fig. 1.

Fig. 1

Ciliate telomeric repeats form G4 DNA structures of greater thermal stability compared to human telomeric repeats. (A) UV Melting curves showing intra-molecular G-quadruplex formation in telomeric ssDNA with flanking sequence. Melting curves for oligonucleotides GT-(TTAGGG)4-TC, GT-(TTAGGG)6-TC, GT-(TTGGGG)4-TC and GT-(TTTTGGGG)4-TC recorded at 295 nm in solutions containing 100 μM KCl. A schematic of one possible G4 conformation for human telomere repeats is shown. Grey balls indicates Gs, and grey lines indicate a quartet formed by base pairing between four Gs. (B) UV melting curves for the olignucleotide GT-(TTTAGGG)10-TC in two different salt solutions, 100 μM KCl and 100 μM NaCl.