Figure 4.

Norepinephrine depletion alters cross-structural coherence. Cross-structural coherence was measured in WT and NET-KO animals after treatment with αMT (250 mg/kg, i.p.). a, b, Each plot depicts select cross-coherence values observed during a baseline behavioral period juxtaposed with cross-coherence values observed 1.5 h after treatment with αMT in WT (left) and NET-KO (right) mice. Treatment with αMT dramatically altered cross-structural coherence across several brain areas in NET-KO mice but not WT mice. c, d, Sample LFP traces recorded from NET-KO mouse before (left) and after (right) treatment with αMT. Red dashed lines highlight theta synchrony during baseline periods. Note that v. striatum theta oscillation peaks fail to synchronize with OFC theta oscillations peaks after treatment with αMT (c) and that v. striatum and VTA theta oscillations become synchronized after treatment with αMT (d). Each trace depicts 2.5 s of continuous LFP activity; n = 6 and 9 for αMT-treated WT and NET-KO mice, respectively.