Figure 5.

Dynamic changes in coherence across cortio-striatal and mesolimbic circuits after NE depletion. a, Partial norepinephrine and dopamine depletion in WT mice attenuated coherence (red) across multiple cortico-striatal, cortico-thalamic, and mesolimbic circuits. b, Profound norepinephrine and partial dopamine depletion in NET-KO mice attenuated coherence (red) across FrA-striato-thalamo-cortical and M1-striatal neural circuits (red) and potentiated coherence (green) across OFC-striato-thalamo-cortical, striato-thalamo-PFC, VTA-striato-thalamic, and PFC-VTA neural circuits. c, Treatment effect of αMT on coherence in NET-KO animals relative to WT mice. Only coherence differences that reached significance are highlighted (*p < 0.05 for comparisons within and across genotype; n = 6 and 9 for αMT-treated WT and NET-KO mice, respectively.