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HSV-1 ICP0-mediated PML degradation is inhibited by IFN-β. Immunofluorescence detection of ICP0 and Sp100A in Daudi cells. Untransfected Daudi cells without IFN (−) or treated with IFN (+) for 24 h (+) are indicated on the left side of the panels. Daudi cells transfected with an ICP0 expression plasmid without IFN (−) or treated with IFN (+) for 24 h (+) are indicated similarly.
