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Function of Ebola virus (EBOV)-encoded IFN-antagonist proteins. (A) EBOV VP35 inhibits IFN-α/β production by interacting with the IRF-3 kinases IKK-ɛ and TBK-1. This prevents efficient phosphorylation of IRF-3, blocking activation of the IFN-β promoter. (B) EBOV VP24 prevents nuclear accumulation of activated, tyrosine-phosphorylated STAT1 through an interaction with NPI-1 family karyopherin-α proteins, which otherwise import dimerized STAT1 into the nucleus.
