Table 1.
Firing properties of inspiratory HMNs in basal conditionsa
| Experimental conditions | n | mFR (sp s−1) | SB (sp burst−1) | BR (bursts min−1) |
|---|---|---|---|---|
| Intact (control) | 47 | 35.7 ± 2.1 | 16.7 ± 1.0 | 45.8 ± 0.8 |
| 7 days post-crushing | 47 | 24.9 ± 2.3* | 11.1 ± 0.9* | 44.7 ± 1.1 |
| AVV-eGFP | 51 | 35.8 ± 1.9 | 16.7 ± 0.9 | 48.1 ± 1.4 |
| AVV-eGFP/AVV-nNOS | 55 | 26.7 ± 1.4*# | 12.1 ± 0.8*# | 50.9 ± 1.4 |
| AVV-eGFP/AVV-nNOS+L-NAME | 32 | 41.6 ± 2.6§ | 20.0 ± 1.6§ | 40.1 ± 1.5#§ |
| AVV-eGFP/AVV-nNOS+7-NI | 34 | 46.0 ± 2.8*#§ | 18.8 ± 1.5§ | 45.4 ± 2.3 |
| AVV-eGFP/AVV-nNOS+ODQ | 28 | 38.2 ± 2.9§ | 17.1 ± 1.4§ | 45.4 ± 1.8 |
| LVV-miR-shRNA/nNOS/AVV-nNOS | 20 | 45.0 ± 2.7§ | 20.0 ± 1.6§ | 44.9 ± 1.7 |
| LVV-miR-shRNA/nNOS/Crush | 31 | 23.7 ± 2.0* | 10.3 ± 0.8* | 50.4 ± 0.9 |
| LVV-miR-shRNA/nNOS/Crush +Dox | 26 | 26.6 ± 2.1* | 8.9 ± 1.0* | 68.6 ± 3.1* |
a
Basal conditions were considered to be when 
= 4.8–5.2%.
n represents the number of motoneurons included in the study. Data values are expressed as means ±s.e.m. At least 3 animals were used for each experimental condition. Significant differences relative to intact/control
*
AVV-eGFP-
#
or AVV-eGFP/AVV-nNOS-injected
§
groups (P < 0.05; one-way ANOVA; post hoc Tukey's test).
mFR, mean firing rate; SB, number of spikes per burst; BR, burst rate.