Figure 2. Kv1.4 is not the remaining β-cell Kv-current when Kv2.1 is inhibited.

A, Kv-current traces from Kv1.4^−/−β-cells in response to a voltage step from −80 mV to 30 mV (blue trace) with 100 nm ScTX (green trace) and 5 μm CP 339818 (orange trace). B, current density vs. voltage plots for β-cells recorded in steps from −80 mV to the indicated voltage (n = 5 for each condition). C, Western blot analysis of mouse islet protein preparation probed with a Kv1.4 specific antibody. Mouse pancreatic section probed with an antibody specific to Kv1.4 (green) and insulin (red) showing non-overlap of the two signals); scale bar 10 μm.