Table 1.

Islets and treatments	A. AP freq. (Hz)	s.d.	B. Membrane potential (mV)	s.d.		t test (samples; P value)
1. Kv2.1−/− 200 mm tolb., 2 mm glucose	0.201	0.035	−46.9	3.15	n = 5	1B, 2B; P = 0.0496
2. Kv2.1−/− 200 mm tolb., 2 mm glucose, 5 μm CP 339818	0.333	0.045	−40.8	1.92	n = 5	1A, 2A; P = 0.0002
3. C57 14 mm glucose*	1.928	0.341	−54.25	6.19	n = 6	3B, 4B; P = 0.0241
4. C57 14 mm glucose, 10 μm CP 339818*	1.642	0.259	−45.542	5.12	n = 6	3A, 4A; P = 0.132
5. Kv1.4−/− 14 mm glucose*	1.791	0.132	−51.667	3.21	n = 4	5B, 6B; P = 0.0302
6. Kv1.4−/− 14 mm glucose, 10 μm CP 339818*	1.533	0.104	−40.583	4.87	n = 4	5A, 6A; P = 0.0516
B. Time to peak (ms)
7. Kv2.1−/− 200 mm tolb., 2 mm glucose	0.216	0.052	295.492	126.9	n = 3	7B, 8B; P = .0139
8. Kv2.1−/− 200 mm tolb., 2 mm glucose, 100 nm apamin	0.072	0.03	905.192	107.3	n = 3	7A, 8A; P = 0.0031
9. C57 200 mm tolb., 100 nm ScTX	0.233	0.056	452.963	104.3	n = 3	9B, 10B; P = 0.0183
10. C57 200 mm tolb., 100 nm ScTX, 100 nm apamin	0.078	0.042	1364.388	305.5	n = 3	9A, 10A; P = 0.00001
11. C57 +tolb	0.841	0.306	129.85	4.738	n = 3	11B, 12B, P = 0.91
12. C57 +tolb+ UCL 1684	1.098	0.429	133.15	37.68	n = 3	11A, 12A; P = 0.44
13. C57+ tolb + ScTX	0.251	0.071	422.6	83.27	n = 4	13B, 14B; P = 0012
14. C57 200 mm tolb., 100 nm ScTX, 10 nm UCL 1684	0.043	0.017	1785.631	215.9	n = 4	13A, 14A; P = 0.00002

^*Frequency taken 5 min post-treatment.