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Distributions of network metrics for subsampled nondisease genes. Network metrics include betweenness centrality (Btw), current information flow (Cif), bridging centrality (Bdg), and clustering coefficient (Clu). Values of network metrics for (A) Mendelian and (B) complex disease genes are shown as vertical red bars. For each distribution, 10,000 replicates of nondisease genes with same number and degree of genes as disease genes were constructed.
