Table 1.

Mean and Variance of Network Measures of Genes

The network measures include degree centrality (k), betweenness centrality (Btw), current information flow (Cif), bridging centrality (Bdg), and clustering coefficient (Clu). All measures, except of Clu, were log10-transformed before computation of mean and variance (inside parentheses). Student's t-tests were conducted to compare the mean between disease and nondisease genes (significance levels: ^nsnot significant; ^*P < 1 × 10⁻³; ^**P < 1 × 10⁻⁵; ^***P < 1 × 10⁻¹⁰). F-tests were conducted to compare the variance between disease and nondisease genes (significance levels: ^nsnot significant; ^#P < 1 × 10⁻⁵; ^##P < 1 × 10⁻¹⁰). Note that Mann–Whitney U test and Levene's test, which are less sensitive to nonnormal distributions, were also used to test equality of means and variances, respectively; similar results were produced (data not shown).