Table 1.
Older adults (age ≥ 50 yr) | Younger adults (age < 50 yr) |
---|---|
Age ≥ 65 yr (both women and men) | Fragility fracture |
Clinical risk factors for fracture (menopausal women, men age 50–64 yr) | Prolonged use of glucocorticoids* |
Fragility fracture after age 40 yr | Use of other high-risk medications† |
Prolonged use of glucocorticoids* | Hypogonadism or premature menopause (age < 45 yr) |
Use of other high-risk medications† | Malabsorption syndrome |
Parental hip fracture | Primary hyperparathyroidism |
Vertebral fracture or osteopenia identified on radiography | Other disorders strongly associated with rapid bone loss and/or fracture |
Current smoking | |
High alcohol intake | |
Low body weight (< 60 kg) or major weight loss (> 10% of body weight at age 25 yr) | |
Rheumatoid arthritis | |
Other disorders strongly associated with osteoporosis |
At least three months cumulative therapy in the previous year at a prednisone-equivalent dose ≥ 7.5 mg daily.
For example, aromatase inhibitors or androgen deprivation therapy.