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. Author manuscript; available in PMC: 2011 Jul 15.
Published in final edited form as: Biochem Pharmacol. 2010 Mar 30;80(2):205–217. doi: 10.1016/j.bcp.2010.03.024

Table 1.

In vivo hemodynamic parameters of hearts from control (C), STZ-diabetic (D), Ag-treated control (Ag-C), Ag-treated STZ-diabetic (Ag-D) and insulin-treated STZ-diabetic (Ins-D) rats. Values shown are mean ± S.E.M (n = 8, from each group).

PARAMETER Control STZ-diabetic Aminoguanidine-treated control Aminoguanidine-treated STZ-diabetic Insulin-treated STZ-diabetic
(C) (D) (Ag-C) (Ag-D) (Ins-D)
(n = 8) (n=8) (n=8) (n = 8) (n = 8)
HEART RATE (bpm)
 Before ISO 338.6 ± 8.5 268.1 ± 18.6* 314.6 ± 10.8# 273.1 ± 32.8 273.1 ± 32.8
 0.1 μg/kg ISO 385.5 ± 12.2 377.6 ± 34.2 362.7 ± 15.3 326.5 ± 31.9 404.1 ± 4.3
 0.25 μg/kg ISO 395.8 ± 12.6 343.1 ± 14.9* 363.1 ± 16.8 333.0 ± 33.9 402.9 ± 4.9
SYSTOLIC BP (mmHg)1
 Before ISO 136.1 ± 10.2 111.2 ± 13.6* 149.8 ± 8.7 109.1 ± 18.7 138.6 ± 4.0**
 0.1 μg/kg ISO 151.8 ± 8.1 129.8 ± 13.5* 162.7 ± 10.8 127.1 ± 19.6 157.1 ± 1.2**
 0.25 μg/kg ISO 149.3 ± 6.9 132.3 ± 10.8 154.9 ± 10.4 124.9 ± 18.2 155.1 ± 5.3**
PEAK LVP(mmHg)2
 Before ISO 133.6 ± 9.4 104.7 ± 6.2* 135.2 ± 8.6 118.4 ± 7.6** 133.9 ± 2.8**
 0.1 μg/kg ISO 133.2 ± 4.4 98.7 ± 7.5* 128.7 ± 7.1 114.9 ± 7.7** 138.0 ± 1.6**
 0.25 μg/kg ISO 129.9 ± 4.3 95.3 ± 7.1* 131.3 ± 6.5 108.1 ± 7.4 123.9 ± 4.6**
LVEDP(mmHg)3
 Before ISO 0.1 ± 0.4 6.6 ± 1.6* 2.1 ± 0.3# 0.5 ± 1.3** 2.0 ± 2.1**
 0.1 μg/kg ISO 1.9 ± 0.8 4.4 ± 1.1 1.4 ± 0.7 2.5 ± 0.5** 2.1 ± 1.8
 0.25 μg/kg ISO 2.3 ± 0.9 2.1 ± 0.4 0.9 ± 0.7 2.7 ± 0.6 1.8 ± 0.2
+dP/dt(mmHg/sec)4
 Before ISO 9954.5 ± 900.5 6521.4 ± 913.6* 11125.9 ± 772.3 9000.7 ± 921.7** 11209.2 ± 450.7**
 0.1 μg/kg ISO 14971.1 ± 1653.4 12659.4 ± 1391.6 17435.4 ± 1771.1 14633.1 ± 708.1 16057.0 ± 525.3**
 0.25 μg/kg ISO 15575.3 ± 1655.7 13067.7 ± 1077.9 17227.1 ± 1697.7 13202.5 ± 1173.8 16329.4 ± 834.3**
−dP/dt(mmHg/sec)5
 Before ISO 8065.5 ± 995.5 5279.6 ± 1096.5* 8983.3 ± 922.1 6777.5 ± 1136.7 7583.9 ± 528.9**
 0.1 μg/kg ISO 9859.6 ± 988.2 7717.3 ± 1275.3* 11386.3 ± 1302.9 8285.4 ± 1564.8 11445.4 ± 1525.5**
 0.25 μg/kg ISO 10711.5 ± 1239.1 7904.8 ± 821.1* 10344.6 ± 1229.9 7431.1 ± 1981.1 10188.3 ± 1530.5**
*

- Significantly different control (p<0.05).

**

- Significantly different from STZ-diabetic (p<0.05).

1

BP - blood pressure,

2

LVP - left ventricular pressure,

3

LVEDP – left ventricular end diastolic pressure,

4

+dP/dt – rate of change of left ventricular pressure increase,

5

−dP/dt – rate of change of left ventricular pressure decrease.