Table 2.

Contractile kinetics of ventricular myocytes isolated from control (C), STZ-diabetic (D), Ag-treated control (Ag-C), Ag-treated STZ-diabetic (Ag-D) and insulin-treated STZ-diabetic (Ins-D) rats. Values shown are mean ± S.E.M for ≥ 75 cells obtained from 5 separate animals from each group.

PARAMETER	Control	STZ-diabetic	Aminoguanidine-treated control	Aminoguanidine-treated STZ-diabetic	Insulin-treated STZ-diabetic
	(C)	(D)	(Ag-C)	(Ag-D)	(Ins-D)
	(n = 76)	(n = 76)	(n = 75)	(n = 80)	(n = 72)
Cell length (μm)	118.3 ± 2.1	116.8 ± 2.1	1193 ± 3.5	115.8 ± 2.8	116.9 ± 2.3
Contraction velocity (μm/sec)
0.5 Hz	136.5 ± 6.0	83.0 ± 4.6*	124.8 ± 5.2	92.4 ± 3.8**	132.5 ± 5.8**
1.0 Hz	141.8 ± 7.8	89.6 ± 5.8*	122.5 ± 7.4	96.3 ± 5.3	126.3 ± 7.8**
2.0 Hz	128.1 ± 6.9	91.9 ± 5.3*	123.8 ± 8.7	106.6 ± 5.6**	132.3 ± 7.8**
Percent cell shortening
0.5 Hz	12.0 ± .45	9.9 ± 0.5*	12.3 ± 0.4	10.5 ± 0.4**	12.4 ± 0.8**
1.0 Hz	12.5 ± 0.6	9.9 ± 0.6*	11.0 ± 0.5	10.1 ± 0.6	11.1 ± 0.6**
2.0 Hz	10.0 ± 0.4	8.8 ± 0.5*	10.3 ± 0.5	9.5 ± 0.5*	11.2 ± 0.6**
Relaxation velocity (μm/sec)
0.5 Hz	92.31 ± 5.4	71.6 ± 4.6*	95.8 ± 5.3	90.0 ± 3.1**	96.0 ± 5.6**
1.0 Hz	97.5 ± 6.8	76.8 ± 5.7*	95.8 ± 7.4	84.0 ± 4.4	91.6 ± 6.4**
2.0 Hz	84.1 ± 5.1	82.1 ± 5.9	97.9 ± 8.6	89.7 ± 6.0	100.7 ± 9.7**
Time to 50% peak contraction (msec)
0.5 Hz	63.1 ± 3.5	90.5 ± 4.0*	70.3 ± 2.1	73.7 ± 1.8**	63.6 ± 2.7**
1.0 Hz	65.9 ± 2.2	84.1 ± 2.1*	72.3 ± 2.4	71.7 ±1.9**	69.1 ± 1.8**
2.0 Hz	52.5 ± 0.1	64.7 ± 1.6*	56.1 ± 0.8	58.3 ± 0.9**	52.6 ± 0.6**
Time to 50% peak relaxation (msec)
0.5 Hz	402.2 ± 11.9	464.9 ± 12.1*	381.8 ± 9.6	417.5 ± 5.6**	359.5 ± 7.8**
1.0 Hz	363.1 ± 9.1	406.8 ± 8.3*	378.0 ± 7.4	379.4 ± 5.3**	333.0 ± 7.0**
2.0 Hz	318.2 ± 5.3	337.7 ± 5.6*	329.5 ± 4.3	327.6 ± 4.2**	285.3 ± 5.3**

^*- Significantly different control (p<0.05).

^**- Significantly different from STZ-diabetic (p<0.05).