Table 1.

Antihyperuricemic drugs in gout

Drug	Action: indication	Daily dose: standard	Characteristics
Allopurinol orally	XOi: all	100–900 mg: 300 mg	Dosage adjustment to renal function
Benzbromarone orally	Urate transporter: low excretor, subject to intolerance or allergy to allopurinol	50–200 mg: 100 mg	Poor efficacy in severe renal function impairment
Febuxostat orally	XOi: all, particularly in Allo intolerance	40–120 mg: 80 mg	No dosage adjustment in renal impairment
Probenecid orally	Urate transporter: low excretor	500–2,000 mg: 1,000 mg	Poor efficacy in moderate to severe renal function
Rasburicase iv	UrO: lytic effect on tophi	Compassionate use: eg, 0.2 mg/kg in 60 min; infusion on d 1, then 1x per wk; (+methylprednisolone 100 mg iv)	Biological
Pegloticase iv	UrO: chronic refractory gout	8 mg every 2–4 wk	Biological

Abbreviations: XOi, xanthine oxidase inhibitor; iv, intravenous; UrO, urate oxidase.