Table 3.
No. of Patients With Relevant Acute Toxicities (CTC version 2.0)
Toxicity | Grade | Treatment |
Total(N = 85) |
||||
---|---|---|---|---|---|---|---|
Gemcitabine + Radiotherapy(n = 43) |
Gemcitabine Alone(n = 42) |
||||||
No. | % | No. | % | No. | % | ||
WBC | All | 39 | 38 | 77 | |||
3 | 7 | 16 | 6 | 14 | 13 | 15 | |
4 | 0 | 0 | 0 | ||||
Neutrophils | All | 32 | 33 | 65 | |||
3 | 12 | 28 | 15 | 36 | 27 | 32 | |
4 | 2 | 5 | 3 | 7 | 5 | 6 | |
Platelets | All | 20 | 18 | 38 | |||
3 | 1 | 2 | 0 | 1 | 1 | ||
4 | 0 | 0 | 0 | ||||
Hemoglobin | All | 42 | 40 | 83 | |||
3 | 2 | 5 | 0 | 2 | 2 | ||
4 | 1 | 2 | 0 | 1 | 1 | ||
SGPT | All | 30 | 29 | 59 | |||
3 | 5 | 12 | 5 | 12 | 10 | 12 | |
4 | 0 | 0 | 0 | ||||
Fatigue | All | 31 | 28 | 59 | |||
3 | 3 | 7 | 2 | 5 | 5 | 6 | |
4 | 0 | 0 | 0 | ||||
Fever | All | 15 | 12 | 27 | |||
3 | 3 | 7 | 0 | 0 | 3 | 4 | |
4 | 0 | 0 | 0 | ||||
Weight loss | All | 10 | 6 | 16 | |||
3 | 1 | 2 | 0 | 0 | 1 | 1 | |
4 | 0 | 0 | 0 | ||||
Anorexia | All | 21 | 8 | 29 | |||
3 | 1 | 2 | 0 | 1 | 1 | ||
4 | 1 | 2 | 0 | 0 | 1 | 1 | |
Nausea | All | 27 | 24 | 51 | |||
3 | 1 | 2 | 0 | 1 | 1 | ||
4 | 0 | 0 | 0 | ||||
Vomiting | All | 20 | 8 | 28 | |||
3 | 0 | 0 | 0 | ||||
4 | 1 | 2 | 0 | 1 | 1 | ||
Gastritis | All | 2 | 0 | 2 | |||
3 | 1 | 2 | 0 | 1 | 1 | ||
4 | 1 | 2 | 0 | 1 | 1 | ||
Diarrhea | All | 26 | 18 | 44 | |||
3 | 0 | 0 | 0 | ||||
4 | 1 | 2 | 0 | 1 | 1 | ||
Hemorrhage | All | 1 | 2 | 3 | |||
3 | 0 | 0 | 1 | 2 | 1 | 1 | |
4 | 1 | 2 | 0 | 0 | 1 | 1 | |
Other GI toxicity | All | 17 | 14 | 31 | |||
3 | 0 | 0 | 0 | ||||
4 | 1 | 2 | 0 | 0 | 1 | 1 | |
Other toxicity | All | 30 | 22 | 52 | |||
3 | 7 | 16 | 2 | 5 | 9 | 11 | |
4 | 1 | 2 | 1 | 2 | 2 | 2 |
Abbreviations: CTC, Common Toxicity Criteria; SGPT, serum glutamic- pyruvic transaminase.