Table A1.

Dose Modifications

Adjustment	Hematologic Toxicities		Nonhematologic Toxicities CTC Grade	% Dose of Chemotherapy
	ANC ×109/L	Platelets ×109/L
Gemcitabine in the control arm and before combination therapy in the experimental arm	1-< 1.5	And/or 75-99	And/or 3	75
	< 1	And/or < 50	And/or 4	Hold; restart at full recovery with 50% dose
Gemcitabine and radiation during combination therapy	0.5-< 1	And/or 50-99	And/or 3	Hold; restart at recovery (grade ≤ 2 toxicity) with 50% dose*

Abbreviations: ANC, absolute neutrophil count; CTC, Common Toxicity Criteria.

^*The decision to hold both radiotherapy and gemcitabine instead of just gemcitabine was left to the investigator's discretion.