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. Author manuscript; available in PMC: 2011 Dec 15.
Published in final edited form as: J Biomed Mater Res A. 2010 Sep 28;95(4):1159–1169. doi: 10.1002/jbm.a.32942

Figure 1.

Figure 1

(A) NMR spectra of dextran aldehyde, (B) L-DOPA, and (C) a 0.3 wt % conjugation of L-DOPA to dextran aldehyde. Following conjugation, the triplet peaks (6.6–6.9 ppm) indicate total L-DOPA content, whereas the imine peak (8.3 ppm) was diagnostic of conjugated L-DOPA. The ratio between the integrals of the triplet and imine peaks was used to calculate the extent of conjugation following reaction, with a 3:1 ratio indicating complete conjugation. (D) The % of initial L-DOPA (▲) and the molar ratio of L-DOPA to constituent aldehyde groups (■) conjugated after reaction are presented as a function of initial L-DOPA concentration to indicate the variation of reaction efficiency and product