Table 2.
Treatment Regimens and Durations by Line of Therapy
| Line of Therapy | No. of Patients | % | No. of Days |
||
|---|---|---|---|---|---|
| Mean | SD | Median | |||
| First | |||||
| FOLFOX + bevacizumab | 434 | 26.2 | 147.2 | 114.4 | 127 |
| FOLFOX | 236 | 14.3 | 92.6 | 68.3 | 72 |
| FOLFIRI + bevacizumab | 153 | 9.2 | 146.2 | 116.5 | 113 |
| Capecitabine | 148 | 8.9 | 59.3 | 54.8 | 37 |
| Bevacizumab + FU/LV | 71 | 4.3 | 152.5 | 108.4 | 134 |
| FU | 56 | 3.4 | 47.8 | 49.1 | 30 |
| FU/LV | 53 | 3.2 | 104.4 | 110.0 | 76 |
| Cetuximab, irinotecan | 52 | 3.1 | 102.9 | 88.0 | 74 |
| FOLFIRI | 47 | 2.8 | 77.1 | 60.5 | 56 |
| Bevacizumab | 43 | 2.6 | 109.9 | 101.3 | 71 |
| Others | 362 | 21.9 | 114.3 | 105.1 | 85 |
| Second | 742 | 44.8 | |||
| FOLFIRI + bevacizumab | 136 | 18.3 | 140.2 | 129.0 | 100 |
| FOLFOX + bevacizumab | 126 | 17.0 | 130.3 | 116.1 | 99 |
| Cetuximab, irinotecan | 63 | 8.5 | 97.3 | 86.3 | 71 |
| Capecitabine | 36 | 4.9 | 64.4 | 84.2 | 41 |
| FOLFOX | 33 | 4.4 | 91.8 | 70.3 | 73 |
| FOLFIRI | 31 | 4.2 | 98.6 | 65.7 | 85 |
| Bevacizumab, capecitabine | 30 | 4.0 | 128.1 | 117.3 | 82 |
| Bevacizumab + FU/LV | 30 | 4.0 | 148.6 | 96.8 | 125 |
| FOLFIRI + cetuximab | 24 | 3.2 | 101.5 | 83.5 | 78 |
| Bevacizumab | 17 | 2.3 | 135.1 | 124.9 | 118 |
| Irinotecan | 17 | 2.3 | 81.9 | 70.8 | 64 |
| Others | 199 | 26.8 | 99.8 | 96.0 | 71 |
| Third | 317 | 19.2 | |||
| Cetuximab, irinotecan | 53 | 16.7 | 84.4 | 77.2 | 57 |
| FOLFIRI + bevacizumab | 29 | 9.1 | 146.8 | 123.5 | 99 |
| FOLFOX + bevacizumab | 23 | 7.3 | 142.8 | 100.5 | 116 |
| Capecitabine | 22 | 6.9 | 67.4 | 54.0 | 54 |
| FOLFIRI | 21 | 6.5 | 77.4 | 68.5 | 57 |
| Panitumumab | 16 | 5.0 | 79.9 | 75.9 | 59 |
| Bevacizumab, irinotecan | 13 | 4.1 | 119.8 | 84.9 | 106 |
| FOLFIRI + cetuximab | 12 | 3.8 | 139.7 | 203.7 | 65 |
| FOLFOX | 12 | 3.8 | 65.3 | 59.9 | 39 |
| Bevacizumab, capecitabine | 11 | 3.5 | 103.9 | 68.6 | 100 |
| Cetuximab | 11 | 3.5 | 60.6 | 32.3 | 59 |
| Others | 94 | 29.7 | 91.8 | 87.4 | 68 |
Abbreviations: FOLFOX, fluorouracil, leucovorin, and oxaliplatin; FOLFIRI, fluorouracil, leucovorin, and irinotecan; SD, standard deviation; FU, fluorouracil; LV, leucovorin.