Table A2.
Treatment Continuum for the Two Most Common First-Line Regimens
| First-Line Therapy | No. | % |
|---|---|---|
| FOLFOX + bevacizumab | 434 | 100 |
| Progressed to subsequent line of therapy | 205 | 47.2 |
| Stopped therapy | 229 | 52.8 |
| Second-line therapy | 205 | 100 |
| FOLFIRI + bevacizumab | 71 | 34.6 |
| Cetuximab + irinotecan | 18 | 8.8 |
| FOLFIRI | 17 | 8.3 |
| Bevacizumab + capecitabine | 12 | 5.9 |
| FOLFOX + bevacizumab | 12 | 5.9 |
| FOLFIRI + cetuximab | 9 | 4.4 |
| Irinotecan | 8 | 3.9 |
| Bevacizumab + FU/LV | 6 | 2.9 |
| FOLFIRI + panitumumab | 6 | 2.9 |
| Bevacizumab | 4 | 2.0 |
| Bevacizumab + capecitabine + irinotecan | 4 | 2.0 |
| Bevacizumab + irinotecan | 4 | 2.0 |
| Capecitabine | 4 | 2.0 |
| Others | 30 | 14.6 |
| First line = FOLFOX + bevacizumab and second line = FOLFIRI + bevacizumab | 71 | 100 |
| Progressed to another line of therapy | 30 | 42.3 |
| Stopped therapy | 41 | 57.7 |
| Third-line therapy | 30 | 100 |
| Cetuximab + irinotecan | 11 | 36.7 |
| Capecitabine | 4 | 13.3 |
| FOLFIRI + bevacizumab | 3 | 10.0 |
| Cetuximab | 3 | 10.0 |
| FOLFIRI + cetuximab | 2 | 6.7 |
| Others | 7 | 23.3 |
| FOLFOX | 236 | 100 |
| Progressed to subsequent line of therapy | 123 | 52.1 |
| Stopped therapy | 113 | 47.9 |
| Second-line therapy | 123 | 100 |
| FOLFOX + bevacizumab | 64 | 52.0 |
| FOLFIRI + bevacizumab | 11 | 8.9 |
| FOLFIRI | 7 | 5.7 |
| FOLFOX | 7 | 5.7 |
| Bevacizumab + 5FU/LV | 6 | 4.9 |
| Capecitabine + oxaliplatin | 4 | 3.3 |
| FOLFOX + cetuximab | 4 | 3.3 |
| Bevacizumab | 3 | 2.4 |
| FOLFIRI + cetuximab | 3 | 2.4 |
| Cetuximab + irinotecan | 3 | 2.4 |
| Others | 11 | 8.9 |
| First line = FOLFOX and second line = FOLFOX + bevacizumab | 64 | 100 |
| Progressed to another line of therapy | 34 | 53.1 |
| Stopped therapy | 30 | 46.9 |
| Third-line therapy | 34 | 100 |
| FOLFIRI + bevacizumab | 6 | 17.6 |
| FOLFIRI | 6 | 17.6 |
| FOLFIRI + cetuximab | 4 | 11.8 |
| Bevacizumab + irinotecan | 3 | 8.8 |
| Capecitabine | 3 | 8.8 |
| Bevacizumab + capecitabine | 2 | 5.9 |
| Others | 10 | 29.4 |
Abbreviations: FOLFOX, fluorouracil, leucovorin, and oxaliplatin; FOLFIRI, fluorouracil, leucovorin, and irinotecan; FU, fluorouracil; LV, leucovorin.