Figure 4.

Beneficial effects of multiple-dose radioimmunotherapy. Mortality and efficacy after one or two doses of ¹³¹I-B72.3 at a weekly interval in mice (left) (graphic generated from data in DeNardo ²⁷ ). Fractionation versus single-dose toxicity in patients (right). Mean toxicity scores (sum of white blood cell count and platelet nadir grade) for groups of patients treated with a total dose of 36 mCi/m² of ¹³¹I-chimeric B72.3 given in one, two, or three weekly fractions (modified from DeNardo et al. ⁴⁹ and Meredith et al. ⁴⁷ ).