Figure 7.

Micro–positron emission tomography tomographic molecular imaging of a mouse obtained 2 hours after intravenous ⁶⁴Cu-labeled SHAL (7.4 MBq; 4 μg). Transverse section shows increased radioactivity in the Raji human non-Hodgkin's lymphoma, but not in the HBT 3477 human breast cancer xenograft, on the right and left lower abdomen, respectively. Raji xenografts express, whereas HBT 3477 xenografts do not express human leukocyte antigen (HLA)-DR10. The xenografts provided positive (Raji) and negative (HBT 3477) controls for HLA-DR10, with which the SHALs were intended to bind (modified and reproduced with permission from DeNardo et al. (DeNardo GL, Natarajan A, Hok S, et al. Pharmacokinetic characterization in xenografted mice of a series of first-generation mimics for HLA-DR antibody, Lym-1, as carrier molecules to image and treat lymphoma. J Nucl Med 2007;48:1338.)