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Chemical structure in 2 dimensions for dimeric selected high-affinity ligand, (DvLPBaPPP)2(Arg)6LLDo, with an Arg6 nuclear localization sequence (upper). SHALs having the Ct ligand, 3-(2-([3-chloro-5-trifluoromethyl)-2-pyridinyl]oxy)-anilino)-3-oxopropanionic acid (lower), selectively residualized and were cytotoxic. (Analog-biotinylated SHALs differ only with respect to the substitution of biotin for the macrocycle chelate, to the upper right of SHAL.)
