. 2008 Aug;23(4):383–397. doi: 10.1089/cbr.2007.0523-U

Table 2.

Validated Methods for Intensification of Therapeutic Effects

• Arm with radionuclide (e.g., ⁹⁰Y or ¹³¹I)

• Treat earlier!

• Radiation dose intensification: “more and longer”

• Larger doses, (e.g., SCT)

• More doses (e.g., multiple doses or fractionation)

• Better-defined patient population, using imaging

• Small molecule radionuclide carriers

• Pretargeted RIT

• mAb alternatives (e.g., mAb fragments, affibodies, aptamers, SHALs, peptides, etc.)

SCT, stem cell transplantation; RIT, radioimmunotherapy; mAb, monoclonal antibody; SHALs, selected high-affinity ligands.