Table 5.
Enriched functions of the 53 over-represented targets in diabetes
| Category | Term | # target | p-value | Fold |
|---|---|---|---|---|
| Biological Processes GO | superoxide metabolic process | 7 | 3.70E-15 | 303 |
| electron transport | 13 | 1.50E-12 | 16 | |
| superoxide release | 5 | 4.20E-11 | 298 | |
| Molecular Functions GO | electron carrier activity | 15 | 1.80E-17 | 27 |
| oxidoreductase activity | 18 | 2.20E-16 | 14 | |
| iron ion binding | 15 | 4.20E-16 | 21 | |
| Cellular Components GO | mitochondrion | 13 | 9.90E-08 | 6 |
| extracellular space | 10 | 6.60E-07 | 8 | |
| soluble fraction | 7 | 3.20E-06 | 11 | |
| Pathway | Leukocyte transendothelial migration | 9 | 6.40E-12 | 36 |
| Small cell lung cancer | 7 | 1.00E-09 | 38 | |
| Formation of Platelet plug | 6 | 1.10E-08 | 41 | |
'#target' refers to the number of ROS-diabetes targets with each biological function with Benjamini-Hochberg adjusted p-values. Fold is the ratio of targets from the ROS-diabetes set to the complete HUGO gene set.